In terms of significant projects and deals, Conan O’Brien made headlines in 2010 when he was briefly appointed as the host of “The Tonight Show” following Jay Leno’s departure. However, due to various network disputes, O’Brien ultimately left NBC and started his own late-night show “Conan” on TBS. This move showcased his resilience and commitment to his craft, solidifying his status as a cultural icon in the entertainment industry. O’Brien has also been involved in various successful comedy tours and live shows, further expanding his creative reach and influence.