In the 2020 NFL Draft, Pittman Jr. was selected in the second round by the Indianapolis Colts, where he quickly made an impact on the team. In his rookie season, he played in 13 games and recorded 40 receptions for 503 yards and one touchdown. Pittman Jr. has since become a key player in the Colts’ offense, known for his strong hands, route running, and ability to make tough catches in traffic.