Du Plessis turned professional in 2013 and began his career with a series of impressive victories, primarily competing in the European circuit. He won titles in organizations such as Extreme Fighting Championship (EFC) and KSW, demonstrating his prowess as a well-rounded fighter. In 2020, Du Plessis made his UFC debut, marking a significant milestone in his career. Since joining the UFC, he has continued to showcase his talent and determination, earning victories and climbing the ranks in the middleweight division.