Garoppolo played college football at Eastern Illinois University, where he was recognized for his impressive passing ability. He was selected by the New England Patriots in the second round of the 2014 NFL Draft. Garoppolo served as a backup to Tom Brady before being traded to the San Francisco 49ers in 2017. He led the 49ers to a Super Bowl appearance in the 2019 season. In 2023, Garoppolo joined the Rams, bringing his experience and skills to the team.