Stafford played college football at the University of Georgia, where he was known for his strong arm and football IQ. He was selected by the Detroit Lions with the first overall pick in the 2009 NFL Draft. Stafford spent over a decade with the Lions, setting numerous franchise records before being traded to the Rams in 2021. His leadership and playmaking ability were crucial in leading the Rams to a Super Bowl victory in the 2021 season.