Jacksonville Jaguars defensive end Dawuane Smoot (91) during the second half of an NFL football game against the Detroit Lions, Sunday, Dec. 4, 2022, in Detroit. (AP Photo/Duane Burleson)

In 2021, Smoot signed a two-year contract with the Buffalo Bills, joining a strong defensive unit led by head coach Sean McDermott. As a member of the Bills, he has continued to impress with his playmaking abilities and tenacity on the field.