Since turning professional, Osorio has competed in numerous WTA and Grand Slam tournaments, steadily climbing the rankings. Known for her agility, strategic play, and mental toughness, she has achieved several notable results. In 2021, she won her first WTA title at the Copa Colsanitas in Bogotá, becoming the first Colombian to win the tournament in nearly a decade. Her consistent performances have helped her establish herself as a formidable competitor on the tour.